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| 产品名称 | Cleaved PARP Mouse Monoclonal Antibody(Mix-mA™) | 反应种属 | H |
| 应用 | WB,IHC | ||
| 配方 | 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. | ||
| 别称 | PARP-1,Poly(ADP ribose) polymerase 1,sPARP1,ADPRT1,ADP ribosyltransferase NAD(+) | ||
| 储存 | Store at -20°C. Stable for one year from the date of shipment. | ||
| 推荐稀释比 | WB 1:2,000-5,000 IHC 1:200-500 | ||
| 特异性 | Antibody can detect endogenous pro and active PARP proteins. | ||
| 背景信息 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1,when these breaks are encountered during DNA replication,the replication fork stalls,and double-strand DNA (dsDNA) breaks accumulate. | ||
| 分子量 | 116KD(Pro),89(Active) | 同型 | IgG1 |
| GeneID | 142 | 理论分子量 | 116KD(Pro),89(Active) |
| SWISS | P09874 | 宿主物种 | Mouse |
| 免疫原 | Synthetic Peptide | 克隆性 | Monoclonal |
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Western blot analysis of Jurkat with Cleaved PARP Mouse mAb diluted at 1:2,000.
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Immunohistochemical analysis of paraffin-embedded Human Tonsil Tissue using Cleaved PARP Mouse mAb diluted at 1:500.